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81377 München christian.haass(at)dzne.de +49 89 4400-46549 Areas of investigation/research focus Hochschulprofessor. Haass started to work on Alzheimer's disease (AD) rein 1990 at a time, when very little welches known about the cellular mechanisms involved. Based on the pathology, which shows invariably the accumulation and deposition of Amyloid ß-peptide (Aß), he focused his work on the generation and metabolism of Aß. Christian Haass hypothesized against the widely accepted general opinion rein this field that Aß may Beryllium produced from its precursor in a physiologically häufig pathway and not necessarily rein a pathological process. Indeed he found by using very simple tissue culture systems that Aß is produced and liberated under physiological conditions. This pivotal finding welches a major breakthrough for the entire field, since it allowed elucidating the molecular principles behind Aß generation as well as the identification of the enzymes (the so-called secretases) involved hinein generation and liberation of the peptide and finally the development of selective inhibitors to therapeutically lower Aß production hinein patients.
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Inhibition of secretases as a therapeutic approach requires detailed knowledge about the physiological functions and biochemical properties of these enzymes to avoid unwanted side effects. Christian Haass welches the first to demonstrate a physiological function for beta-secretase. He showed that this protease is critically required for the regulation of myelination. Furthermore, he identified a novel APP processing pathway, which was overlooked for more than 20 years and which has strong implications for clinical trials using beta-secretase inhibitors. He welches also the first to identify the highly complicated subunit composition of gamma-secretase. All these findings not only helped to understand several signaling pathways critically involved hinein brain development (such as myelination and cell differentiation) but also provided the basis for several current therapeutic approaches.
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Leichte zweirädrige Kraftfahrzeuge mit einer durch die Bauart bestimmten Höchstgeschwindigkeit von nicht eine größere anzahl wie 45 sachen, einer Nenndauerleistung/Nutzleistung von nicht eine größere anzahl wie 4 kW des weiteren einem Verbrennungsmotor mit einem Hubraum von nicht etliche denn 50 cm³ oder einer anderen Antriebsform.
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Was ich am besten fand waren die Fahrstunden mit Joachim, wirklich überprüfe hier ein toller Fahrlehrer bei dem du wirklich das Gefühl bekommst das es ihn spaß macht dir das alles beizubringen. Wurde es ans herz legen An dieser stelle dein Fluorührerschein nach machen und wenn es m…
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Where can I find an economical first-aid course? We also offer courses daily hinein the Munich city area. They are all held hinein classrooms adjacent to U/S-Bahn stations. Moosach
Leichte vierrädrige Straßen-Quads mit einer Nenndauerleistung/Nutzleistung von nicht eine größere anzahl denn 4 kW ansonsten vierrädrige Leichtkraftfahrzeuge mit einer Nenndauerleistung/Nutzleistung von nicht eine größere anzahl wie 6 kW, jeweilig mit nicht mehr als beide Sitzplätzen, einer durch die Bauart bestimmten Höchstgeschwindigkeit von nicht eine größere anzahl wie 45 stundenkilometer, einer maximalen Leermasse von 425 kg ansonsten einem Fremdzündungsmotor mit einem Hubraum von nicht eine größere anzahl wie 50 cm³ oder einem Selbstzündungsmotor mit einem Hubraum von nicht mehr als 500 zentimeter³ oder einer anderen Antriebsform.
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